Clinical Trial – Normative Datasets for Assessments Planned for Mild Traumatic Brain Injury (NORMAL)
The purpose of the research study is to collect information about brain function and
structure among active duty military personnel or civilians who are healthy. Researchers want
to develop a database from normal volunteers that will be used in comparison with a similar
database from active duty military with post-concussive syndrome (PCS) from a mild traumatic
brain injury. Findings from this study may be used to design larger studies that will
evaluate whether hyperbaric oxygen treatments actually improve PCS.
Participants in this study will undergo numerous tests to assess physical, mental, and
intellectual health and how they might change over time. Participants will wear heart and
activity monitors, undergo brain imaging, provide blood and urine for laboratory testing, and
have vision, hearing, balance, and muscle function tests. They will also complete a number of
questionnaires and interviews. This battery of tests will be repeated twice more over the
course of 6 months.
Clinical Trial – Effects of Dexmedetomidine Premedication on Geriatric Patients With Chronic Renal Failure Undergoing Hip Surgery
Geriatric patients (age ≥ 65 years) undergo surgery for hip fractures that develops due to
osteoporosis and falls. Dialysis-dependent chronic kidney disease is associated with an
increased risk of cardiovascular comorbidity. Elective or urgent surgical operations may be
required for geriatric patients with end stage renal disease. These patients have severe
comorbidities, fluid, electrolyte disturbances and drug metabolism abnormalities during the
perioperative period. For this reasons a careful anesthesia plan should be planned and
performed. Spinal anesthesia can be used for hip fracture surgery at geriatric patients with
chronic renal failure. Anterograde femoral intramedullary nailing can be performed in supine
position with a fracture table. Intraoperative sedation might be necessary for patients under
regional anesthesia on traction table. Dexmedetomidine is an alpha 2 receptor agonist that is
being used as an agent for its sedative and adjuvant analgesic effects.
The aim of this study is to evaluate the effects of dexmedetomidine premedication on
geriatric patients with end stage renal disease, who will be undergoing a surgical operation
for hip fracture under spinal anesthesia with hyperbaric bupivacaine and BIS (Bispectral
Index) guided sedation with intraoperative propofol infusion.