A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and post-traumatic stress disorder.

This is a preliminary report on the safety and efficacy of 1.5 ATA hyperbaric oxygen therapy (HBOT) in military subjects with chronic blast-induced mild to moderate traumatic brain injury (TBI)/post-concussion syndrome (PCS) and post-traumatic stress disorder (PTSD). Sixteen military subjects received 40 1.5 ATA/60 min HBOT sessions in 30 days. Symptoms, physical and neurological exams, SPECT brain imaging, and neuropsychological and psychological testing were completed before and within 1 week after treatment. Subjects experienced reversible middle ear barotrauma (5), transient deterioration in symptoms (4), and reversible bronchospasm (1);

Clinical Trial – The Effect of Hyperbaric Oxygen Therapy on Patients Suffering From Neurologic Deficiency Due Traumatic Brain Injury

Traumatic brain injuries (TBI) are a major cause of morbidity and mortality worldwide. Due to
improvements in emergency medical care, transportation and specialized trauma facilities, the
number of people surviving TBI with impairment has significantly increased in recent years.
The long term cognitive sequelae, which are often not visible persist far beyond the
resolution of the obvious physical disabilities. This combined with the relatively low
awareness of the general public has designated TBI as the "silent epidemic" (TBI CDC 2006).
Hyperbaric oxygen therapy (HBOT) has been suggested as a possible treatment modality for
these cases and preliminary studies are promising.

The purpose of this study is to evaluate the effectiveness of HBOT in the treatment of
chronic mild traumatic brain injuries (mTBI). Sequential SPECT scans of the brain and
neurocognitive testing will be used to evaluate cerebral blood flow (CBF) response, cognitive
and functional improvement following treatment.