Clinical Trial – Hyperbaric Oxygen Therapy for Inflammatory Conditions of the Urinary Bladder

Pilot study to determine feasibility for treating patients with two chronic inflammatory
conditions of the urinary bladder: chronic interstitial cystitis and recurrent urinary tract
infections using a standardized hyperbaric oxygen treatment plan. Presently there are no good
treatments for these conditions and hyperbaric oxygen may be a safe and readily accessible
therapy as it has proven successful an another type of chronic inflammatory condition of the
urinary bladder known as "radiation cystitis". The study will determine if patients will
consider this an acceptable treatment for their conditions and that it is well tolerated.

Clinical Trial – GA/Spinal vs. GA/Spinal/NMB for Operative Repair of Hip Fracture

Surgical repair of hip fractures may be performed with various anesthetic techniques, but are
most commonly completed under general anesthesia (GA) or neuraxial anesthesia (NA). Numerous
prospective and retrospective studies demonstrate improved morbidity and mortality when NA is
used; however, many surgeons prefer the use of GA with neuromuscular blockade (NMB) due to
the perception of better operative conditions. This study aims to compare the operative
conditions obtained from the use of combined GA and spinal with NMB vs. the use of GA with
spinal without NMB. 84 patients will all receive a single shot spinal and GA and then will be
randomized to receive either NMB or placebo. The fracture reduction time will be measured.

Clinical Trial – Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study

The investigators will analyze biomarkers related to the prognosis and treatment of
necrotizing soft tissue infections (NSTI). The focus will be on whether certain endothelial
and immune system biomarkers can function as markers of disease severity, mortality as well
as the effects of hyperbaric oxygen therapy (HBOT). Biomarkers will be measured upon
admission to an intensive care unit at Copenhagen University Hospital and during the
following 3 days.