Clinical Trial – ET 50 for Post Caesarean Section Spinal Hypotension
Hypotension is extremely common after induction of spinal anesthesia for cesarean delivery.
Anesthetic blockade of the sympathetic outflow of the spinal cord causes vasodilation, and is
one cause of this hypotension. The higher the spread of the blockade will result in a higher
incidence of hypotension. Injected hyperbaric medication has about 15 minutes to spread
within the intrathecal space before it will be taken up by the nerve roots. The time that a
patient remains in one position after medication injection will affect the spread of the
resultant anesthetic block. A patient who is left sitting for a longer period of time after
injection of hyperbaric medication will have a lower level of block than someone who is
placed supine immediately. In this study, the investigators wish to use up down sequential
analysis to determine the time period a patient should remain seated after intrathecal
injection of hyperbaric bupivacaine that will result in a 50% rate of hypotension.
Clinical Trial – Dose Finding Study for Continuous Spinal Anaesthesia
Fixation of fractured neck of femur is a common Orthopedic surgery. Anaesthesia can be
challenging in some cases like in haemodynamical unstable patients.
The investigators have evidence of minimum effective local anaesthetic dose (MLAD) in hip
replacement surgery but MLAD to achieve surgical anaesthesia for operative fixation of FNF is
still unknown.
A step-up/step-down methodology was used successfully in regional anaesthesia and also in
other areas of anaesthesia.
In pregnant ladies in whom spinal anaesthesia is performed on the side, significant
correlation exist between the vertebral length measured from cervical 7 to the iliac creast
and MLAD.
The investigators aim it was to determine the MLAD of hyperbaric 0.5% bupivacaine required
for Continuous spinal anaesthesia for the operative fixation of FNF.
Clinical Trial – Recovery of Bupivacaine or Bupivacaine-Lidocaine Spinal Anesthesia and Infiltration Anesthesia in Herniorrhaphy
The purpose of this study is the investigation of whether adding lidocaine to hyperbaric
bupivacaine could decrease the duration of bupivacaine spinal block and provide shorter
recovery and discharge times than local infiltration anesthesia in outpatient herniorrhaphy
procedures.