Clinical Trial – Hyperbaric Oxygen Therapy in Sickle Cell Pain

Hyperbaric oxygen therapy in acute sickle cell pain crisis. The purpose of this study is to
explore if hyperbaric oxygen therapy would decrease hospital length of stay and pain
associated with acute sickle cell pain crisis. Eligibility criteria include both female and
males age 19 years or older with sickle cell who are in an acute pain crisis. Exclusions
include pregnancy and a sickle cell crisis complicated by any acute significant concomitant
factors/conditions (i.e., acute chest syndrome, acute MI/stroke). Interventions would be 1-3
hyperbaric oxygen sessions depending on response to the therapy. Each treatment session will
be approximately two hours in length. Evaluation would be through patients’ self assessment
via the visual analog scale for pain level before and after treatments as well as tracking
length of stay in the hospital.

Clinical Trial – Peripheral Analgesia in Painful Diabetic Neuropathy

Chronic obliterative arteriopathy of the inferior limbs is a frequent condition observed in
diabetics. The later stages induce pain at rest and trophic disorders (ulcer, gangrene) that
lead to chronic limb ischemia. Without possible surgical revascularization ,pain management
and tissue healing are used to avoid amputation.

Prevalence of diabetes is twice higher in Reunion Island than in metropolitan France. As a
consequence, the rate co-morbobidities, such as chronic obliterative arteriopathy of the
inferior limbs, is also increases.

This study compares the efficiency of two analgesic treatments in diabetics with forefoot
injuries.

Clinical Trial – Acute Postthoracotomy Pain – Impact of Gender

Adequate analgesia in thoracic surgery is essential to prevent severe postoperative
complications, especially respiratory problems. Current knowledge about gender-related
differences in pain states generally more frequent and intense pain and more demand for
analgesics in women. Results about postsurgical pain in particular are very inconclusive.

The investigators tried to find out if gender has an influence on postthoracotomy pain and
analgesics requirement.