İn this study; it was aimed to investigate the effects of equipotent doses of hyperbaric
bupivacaine and hyperbaric levobupivacaine in outpatient anorectal surgery under saddle
block. Sixty patients between the age of 18- 50 and in the risk group of ASA I-II included in
the study. 7,5 mg of 0,5% hyperbaric bupivacaine or 7,5 mg of 0,5% hyperbaric levobupivacaine
injected into the intrathecal space in sitting position through L4-L5 or L5-S1 intervertebral
space in 30 seconds. All patients kept in sitting position for 5 minutes with aid after
intrathecal injection and than layed in supine position, finally they positioned in prone
jack-knife. Hemodynamic parameters like NIBP, HR, SpO2, sensory and motor block
characteristics, duration of analgesia, time of first voiding, mobilization time, patient and
surgeon satisfaction, adverse effects and discharge time were recorded during and after
surgery.
Clinical Trials
Clinical Trial – Subarachnoid Bupivacaine in Obese Patients Undergoing Cesarean Delivery
This study evaluates the effect of subarachnoid hyperbaric bupivacaine on mean arterial blood
pressure (MAP) of pregnant patients with obesity undergoing cesarean section half of the
patients will receive subarachnoid hyperbaric bupivacaine at a dose of 5 mg while the other
half will receive a dose of 10 mg
Clinical Trial – Use of Intrathecal Analgesia in Appendectomy
Acute appendicitis which is the most common cause of acute abdominal pain, is an acute
inflammation of appendix vermiformis. Appendectomy operations can be performed as
laparoscopic and open surgery. Addition of opioids to intrathecal local anesthetics to
improve the quality of preoperative analgesia is an increasingly used method in recent years.
The aim of this study is to compare bupivacaine-fentanyl and bupivacaine-alfentanil which are
used intrathecally to create motor and sensory block. 50 volunteer patients who were
diagnosed as appendicitis by laboratory tests and clinical diagnostic methods in general
surgery clinic and classified as American Society of Anesthesiologists Classification I-II
(ASA Class I-II) aged between 20-60 years scheduled for laparoscopic appendectomy operation,
were included in this study. The patients were randomly assigned into two groups, Group I and
Group II. Patients received spinal anesthesia with either 10 mg heavy bupivacaine (2 cc)+25
mcg fentanyl (0.5 cc) intrathecally (Group I, n=25) or 10 mg heavy bupivacaine (2 cc)+250 mcg
alfentanil (0.5 cc) intrathecally (Group II, n=25).
Clinical Trial – Intrathecal Additives to Prevent Post Spinal Shivering in Transurethral Prostatectomy
Spinal anesthesia is the technique of choice in transurethral prostatectomy.However,one of
the common complications of spinal anesthesia is shivering which is even exaggerated in
patients undergoing transurethral prostatectomy.this high incidence is most probably caused
by sympathetic block and use of large amount of irrigation fluid during surgery.There are two
methods to reduce shivering.Previous studies showed that intrathecal fentanyl is an
appropriate method to reduce shivering.Intrathecal dexamethasone could reduce shivering by
regulating immune responses.
Clinical Trial – Inner and Middle Ear Effects of Hyperbaric Oxygen Thrapy
Audiological evaluation performed to patients on hyperbaric oxygen therapy to see its effects
on middle ear pressure
Clinical Trial – The Effect of Hyperbaric OxygeN Therapy on brEast Cancer Patients With Late Radiation toxicitY – UMBRELLA HONEY Trial
The "Hyperbaric OxygeN therapy on brEast cancer patients with late radiation toxicity"
(HONEY) trial aims to evaluate the effectiveness of HBOT on late radiation toxicity in breast
cancer patients using the trial within cohorts (TwiCs) design.
Clinical Trial – Effect of Intravenous Magnesium on Post-spinal Fentanyl Induced Pruritus Incidence
Introduction: Adding opioids to local anesthetic solutions leads to enhanced anesthesia and
provide postoperative analgesia. Intrathecaly injected opioids have some side effects,
though. One of them is pruritus. Objective: We designed a randomized, double‐blinded,
placebo‐controlled study to evaluate prophylactic impact of continuous IV Magnesium 10mg/kg
over 30 minutes on intrathecal fentanyl‐induced pruritus start at the end of the operation.
Methods: ASA I‐II Patient’s candidate for orthopedic operations under spinal anesthesia
(10‐15mg hyperbaric bupivacaine and 25 µg fentanyl intrathecal) and will be divided randomly
into two groups:
Control group (Placebo group): bolus 100 ml nacl 0.9% at end of surgery Study group (Mg ++
group): (continuous IV Magnesium 10mg/kg in 100 ml Nacl0.9% over 30 minutes at end of
surgery).
Study outcome:
1. Hemodynamics: Systolic blood pressure, Mean arterial blood pressure, pulse rate, O2
saturation will be recorded in 5 min,10 min,30 min,60 min and every one hour till 6
hours after the operation.
2. Pruritus Patients were asked about existence (present=1,no=0), severity (mild=1,
modret=2, sever =3) and site of pruritus (Face(trigeminal) =1, neuroaxial(dermatome)=2),
1,2,4, and 6 hours after operation. Incidence of pruritus total group incidence %.
3. The incidence of PONV.
Clinical Trial – Hyperbaric Oxygen Therapy After Stroke – PILOT
The goal of this pilot study is to establish more information about hyperbaric oxygen therapy
for this group of patients, and give us more information of how to initiate the best possible
main study. Can we find any indications that support the use of this therapy for patients
suffering from chronic disability after cerebral infarction? Can we improve physical and
cognitive function.
Clinical Trial – Treatment of Sudden Deafness With Prednisone+Hyperbaric Oxygen and Prednisone+Somatosensory Stimulation
To study the effective treatment of sudden deafness by giving prednisone, hyperbaric oxygen
and somatosensory stimulation to sudden deafness patients.
Clinical Trial – Effect of Intravenous Dexmedetomidine on Patient Discomfort in Laparoscopic Cholecystectomy Under Spinal Anesthesia.
Laparoscopic cholecystectomy (LC) has been routinely performed under general anesthesia
despite the several disadvantages of general anesthesia compared to regional anesthesia.
There are multiple reports that have been published regarding the feasibility of spinal
anesthesia for LC associated with many problems such as referred shoulder pain secondary to
intra-abdominal pneumoperitoneum; patient anxiety, pain, and discomfort; and inadequate
sedation.The aim of our study is to prospectively observe the feasibility of using
intravenous dexmedetomidine to abolish patient discomfort and shoulder pain, thus making the
patient more comfortable without causing excessive sedation and respiratory depression.