The purpose of this research is to see if people who have had a collapsed lung that has been
re-expanded can be safely taken to an elevation that a person might experience while in a
commercial airplane without having their lung partially collapse again, or have any symptoms
such as feeling short of breath or having oxygen levels in the blood decrease while at the
simulated altitude.
The investigators hypothesize that subjects who have had a collapsed lung that has been
re-expanded will not have any adverse symptoms or signs while subjected to a simulated
altitude of 8400 feet (565mm Hg) or 12650 ft (471mm Hg).
The investigators can summarize intrathecal clonidine can potentiate bupivacaine thereby
bringing about better quality and longer duration of analgesia, better sedation and better
postoperative outcomes with minimal side effects.
The primary objective of this study is to assess the relief of symptoms after Hyperbaric
Oxygen Therapy (HBOT) in patients with late radiation cystitis by having Expanded Prostate
cancer Index Composite (EPIC)symptom estimation scale as primary variable.
Study hypothesis:
– HBOT can reduce or reverse the change or otherwise limit the damage of the bladder
function and/or structure, which arose as a result of radiation therapy of cancer in the
pelvic region organs.
– The effects of HBOT are associated with relief of symptoms that, at least in part, is
related to the reduction of the extent of the radiation damage.
– Vascular density increases, fibrosis prevalence and inflammatory activity are reduced as
a sign of an improved function of the mucosa.
– Treatment results of HBOT remains, in whole or in part, during the follow-up (residual
effect)
Recently many studies reported that intraoperative dexmedetomidine administration undergoing
spinal anesthesia give a satisfactory sedation in elderly patients and cause less respiratory
depressions compared other sedatives(e.g. benzodiazepine) But the optimal dose of
dexmedetomidine for sedative effect in elderly patients undergoing spinal anesthesia was not
got general consensus.
The investigators hypothesized that the dose requirements would be lower than in elderly
patients than young patients. Furthermore, intrathecal small dose opioids enhance the
analgesia provided by bupivacaine due to synergistic effects and it would reduce the dose of
dexmedetomidine.
The purpose of this study was to determine the dose of dexmedetomidine to provide
satisfactory sedation undergoing spinal anesthesia with or without additive small dose
intrathecal opioids.
Elderly patients(65~85 years old) undergoing TURP or TURB were enrolled in this
single-blinded study. Forty patients were randomly assigned to receive intrathecal hyperbaric
bupivacaine 6mg coadministered with 20mcg fentanyl or placebo normal saline 0.4cc. After the
induction (bilateral T10 sensory level to pinprick within 5 mins of intrathecal drug
administration), continuous intravenous dexmedetomidine was started in dose of 0.8, 0.6, 0.5,
0.4, 0.3, or 0.2mcg. Successful sedation was defined as OASS score 3 or 4 within 20 minutes
of dexmedetomidine infusion. The dose of dexmedetomidine was selected for each patient
according to an up and down method. Intraoperative arterial pressure, heart rate, and
bispectral index was compared. Postoperative pain score, the time for the regression of
sensory and motor was recorded for further analysis.
The purpose of this study is to investigate whether the dural sac volume as determined by a
geometrical calculation following multilevel measurements of its transverse area and length
by ultrasound imaging, correlates with the intrathecal spread of a single dose of hyperbaric
bupivacaine in a non-obstetrical population.
Purpose of this study is to investigate the mechanisms of action of hyperbaric oxygen therapy
for persistent post-concussive symptoms after mild tramatic brain injury
Hypotension is extremely common after induction of spinal anesthesia for cesarean delivery.
Anesthetic blockade of the sympathetic outflow of the spinal cord causes vasodilation, and is
one cause of this hypotension. The higher the spread of the blockade will result in a higher
incidence of hypotension. Injected hyperbaric medication has about 15 minutes to spread
within the intrathecal space before it will be taken up by the nerve roots. The time that a
patient remains in one position after medication injection will affect the spread of the
resultant anesthetic block. A patient who is left sitting for a longer period of time after
injection of hyperbaric medication will have a lower level of block than someone who is
placed supine immediately. In this study, the investigators wish to use up down sequential
analysis to determine the time period a patient should remain seated after intrathecal
injection of hyperbaric bupivacaine that will result in a 50% rate of hypotension.
Fixation of fractured neck of femur is a common Orthopedic surgery. Anaesthesia can be
challenging in some cases like in haemodynamical unstable patients.
The investigators have evidence of minimum effective local anaesthetic dose (MLAD) in hip
replacement surgery but MLAD to achieve surgical anaesthesia for operative fixation of FNF is
still unknown.
A step-up/step-down methodology was used successfully in regional anaesthesia and also in
other areas of anaesthesia.
In pregnant ladies in whom spinal anaesthesia is performed on the side, significant
correlation exist between the vertebral length measured from cervical 7 to the iliac creast
and MLAD.
The investigators aim it was to determine the MLAD of hyperbaric 0.5% bupivacaine required
for Continuous spinal anaesthesia for the operative fixation of FNF.
The purpose of this study is the investigation of whether adding lidocaine to hyperbaric
bupivacaine could decrease the duration of bupivacaine spinal block and provide shorter
recovery and discharge times than local infiltration anesthesia in outpatient herniorrhaphy
procedures.
This study is undertaken to determine the effect of intravitreal long acting dexamethasone
implant, (Ozurdex®) in improving outcome of cataract surgery in patients with diabetic
macular edema.
Diabetic Macular Edema and cataract constitute important causes of visual impairment in
patients with diabetes. Cataract surgery in patients with diabetic retinopathy is associated
with progression of retinopathy.
Several modalities such as non-steroidal anti-inflammatory agents, carbonic anhydrase
inhibitors, corticosteroids, hyperbaric oxygen, laser photocoagulation and vitrectomy with
internal limiting membrane peeling have been tried for managing inflammatory cystoid macular
edema.
Intravitreal Triamcinolone Acetonide (TA), a water insoluble steroid, has been shown to
reduce the retinal thickness and improve the visual acuity. However, recurrence of macular
edema in patients who receive intravitreal TA is a major concern as the patients need
multiple repeat injections.
In search for the ideal corticosteroid preparation, a Dexamethasone Posterior Segment Drug
Delivery System (Dexamethasone DDS – Ozurdex®, Allergan Inc, Irvine, California) was recently
developed. Promising results have been shown in certain patients with persistent diabetic
macular edema receiving this intravitreal drug delivery system with improvement in visual
acuity
The present study introduces a novel concept of using intraoperative Ozurdex ® implant in
patients with diabetes mellitus while undergoing cataract surgery to minimize the worsening
of diabetic maculopathy.
