The "Hyperbaric OxygeN therapy on brEast cancer patients with late radiation toxicity"
(HONEY) trial aims to evaluate the effectiveness of HBOT on late radiation toxicity in breast
cancer patients using the trial within cohorts (TwiCs) design.
HBOT Research
Clinical Trial – Effect of Intravenous Magnesium on Post-spinal Fentanyl Induced Pruritus Incidence
Introduction: Adding opioids to local anesthetic solutions leads to enhanced anesthesia and
provide postoperative analgesia. Intrathecaly injected opioids have some side effects,
though. One of them is pruritus. Objective: We designed a randomized, double‐blinded,
placebo‐controlled study to evaluate prophylactic impact of continuous IV Magnesium 10mg/kg
over 30 minutes on intrathecal fentanyl‐induced pruritus start at the end of the operation.
Methods: ASA I‐II Patient’s candidate for orthopedic operations under spinal anesthesia
(10‐15mg hyperbaric bupivacaine and 25 µg fentanyl intrathecal) and will be divided randomly
into two groups:
Control group (Placebo group): bolus 100 ml nacl 0.9% at end of surgery Study group (Mg ++
group): (continuous IV Magnesium 10mg/kg in 100 ml Nacl0.9% over 30 minutes at end of
surgery).
Study outcome:
1. Hemodynamics: Systolic blood pressure, Mean arterial blood pressure, pulse rate, O2
saturation will be recorded in 5 min,10 min,30 min,60 min and every one hour till 6
hours after the operation.
2. Pruritus Patients were asked about existence (present=1,no=0), severity (mild=1,
modret=2, sever =3) and site of pruritus (Face(trigeminal) =1, neuroaxial(dermatome)=2),
1,2,4, and 6 hours after operation. Incidence of pruritus total group incidence %.
3. The incidence of PONV.
Is There an Association Between Hyperbaric Oxygen Therapy and Improved Outcome of Deep Chemical Peeling? A Randomized Pilot Clinical Study.
Abstract: Phenol chemical peeling (PCP) treatment is associated with prolonged recovery and sustained adverse events. Hyperbaric oxygen therapy (HBOT) is known to accelerate wound healing. The purpose of the current study was to evaluate the effect of HBOT on PCP...
Clinical Trial – Hyperbaric Oxygen Therapy After Stroke – PILOT
The goal of this pilot study is to establish more information about hyperbaric oxygen therapy
for this group of patients, and give us more information of how to initiate the best possible
main study. Can we find any indications that support the use of this therapy for patients
suffering from chronic disability after cerebral infarction? Can we improve physical and
cognitive function.
Clinical Trial – Treatment of Sudden Deafness With Prednisone+Hyperbaric Oxygen and Prednisone+Somatosensory Stimulation
To study the effective treatment of sudden deafness by giving prednisone, hyperbaric oxygen
and somatosensory stimulation to sudden deafness patients.
Clinical Trial – Effect of Intravenous Dexmedetomidine on Patient Discomfort in Laparoscopic Cholecystectomy Under Spinal Anesthesia.
Laparoscopic cholecystectomy (LC) has been routinely performed under general anesthesia
despite the several disadvantages of general anesthesia compared to regional anesthesia.
There are multiple reports that have been published regarding the feasibility of spinal
anesthesia for LC associated with many problems such as referred shoulder pain secondary to
intra-abdominal pneumoperitoneum; patient anxiety, pain, and discomfort; and inadequate
sedation.The aim of our study is to prospectively observe the feasibility of using
intravenous dexmedetomidine to abolish patient discomfort and shoulder pain, thus making the
patient more comfortable without causing excessive sedation and respiratory depression.
Clinical Trial – The Efficacy of Pain Control After Total Hip Replacement Between Ultrasound Guided Supra-inguinal Fascia Iliaca Block and Intrathecal Morphine
Total hip replacement is one of major orthopedic surgery which result in severe postoperative
pain especially at first 24 hours. Ultrasound guided regional anesthesia has become a part of
multimodal analgesia.Ultrasound guided supra-inguinal fascia iliaca block is a new technique
which can consistently cover femoral and lateral femoral cutaneous nerve. And with large
volume (40ml), it may cover obturator nerve. This technique already proved to be useful for
acute pain control in hip fracture or postoperative control in dynamic hip screw or nail
insertion operation. However, it has not been compared with intrathecal morphine for total
hip replacement yet.
Clinical Trial – Intrathecal Bupivacaine-fentanyl and Bupivacaine-dexmedetomidine for Elective Low Segment Caesarean Section
the primary objective of the study is to compare the onset and recovery times of sensory and
motor blockade of the two study drugs intrathecally with low dose bupivacaine The secondary
objectives of the study are to observe hemodynamics, side effects profile, and duration of
postoperative analgesia
Clinical Trial – Acute Hyperbaric Oxygen (HBO) Treatment Increases Hepatic Insulin Sensitivity and Muscle Reactive Oxygen Species in Type 2 Diabetes
Diabetes mellitus type 2 (T2D) is characterized by insulin resistance of liver and skeletal
muscle, which is at least partly due to impaired muscle mitochondrial function. Long-term HBO
therapy, as applied for treating the diabetic foot syndrome, has been shown to improve blood
glucose concentrations. To study the underlying mechanisms, we want to examin the short-term
effect of HBO treatment on insulin sensitivity and mitochondrial oxidative capacity and
production of reactive oxygen species (ROS) in a randomized, double blinded,
placebo-controlled cross-over trial.
Clinical Trial – Height Versus Height and Weight Based Spinal Bupivacaine on Maternal Haemodynamics for Elective Cesarean in Short Stature Patients
Doses of intrathecal bupivacaine based on patients either height or height and weight has
shown to lower the risk of maternal hypotension with similar quality of anesthesia compared
to conventional doses.
In clinical practice there is a tendency of reducing the dose of bupivacaine as either low
fixed dose or using the doses based on either height and weight or height (0.06mg/cm) alone
in parturient with short stature. However, there is lack of evidence regarding the
appropriate dose required in this group of patients. Therefore, our aim is to compare the
height versus height and weight based intrathecal bupivacaine dose for elective caesarean on
maternal haemodynamics in short stature patients.