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Recent HBOT News
Clinical Trial – SOFT Block Versus Spinal Anesthesia in Patientsusing Ilizarov External Fixator
Peripheral nerve block is an ideal choice for lower limb surgery because of the peripheral
site of the surgical procedure and the ability to block pain pathways at multiple levels. On
the contrary to other anesthetic techniques, as spinal or general anesthesia, properly
performed peripheral nerve blocks bypass adverse events as hemodynamic instability and
respiratory complications, properly treat post-operative pain leading to early hospital
discharge. Additional advantages of peripheral nerve blocks are that they can be used in
patients receiving anti-coagulants or lumbosacral disease in addition to avoidance of airway
instrumentation.
Recently, there has been a significant interest in regional anesthesia and peripheral nerve
blockade. This is facilitated by a significant advance of the research in this field and
availability of better equipment facilitating regional anesthesia.The aim of this study was
to assess the efficacy and safety of SOFT block (sciatic-obturator-femoral nerve block
technique) in comparison with spinal anesthesia in patients undergoing surgery for fixation
of open tibial fractures using Ilizarov external fixator.
Clinical Trial – Effect of Intrathecal Morphine on Chronic Pain After Elective Caesarean Section
The incidence of chronic post-surgical pain (CPSP) after caesarean section (CS) is reported
to be as high as 18%, reflecting it to be a significant clinical problem. Studies related to
prevention of progression of acute post-CS pain to its chronicity are sparse. Current
guidelines on post-CS analgesia recommend the use of intrathecal (IT) opioids to spinal
anaesthesia for improved post-CS pain relief. Despite its frequent use, studies related to
the IT morphine use and its association with post-CS chronic pain are lacking.
A recent prospective observation study revealed a significant reduction in persistent pain
after CS when IT morphine was used as an adjuvant to spinal anaesthesia. However, there is no
any randomized controlled trial (RCT) that has explored this association to date. We
hypothesized that spinal morphine would reduce the incidence of persistent pain after CS.
Long non-coding RNA LINC00152 promotes cell growth and invasion of papillary thyroid carcinoma by regulating the miR-497/BDNF axis.
Abstract: Long intergenic non-coding RNA 152 (LINC00152) was reported to be tightly linked to tumorigenesis and progression in multiple cancers. However, its biological role and modulatory mechanism in papillary thyroid carcinoma (PTC) has not been elucidated. In this...