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Recent HBOT News
Clinical Trial – Estimation of the ED95 of Intrathecal Hyperbaric Prilocaine 2% With Sufentanyl for Scheduled Cesarean Delivery
Hyperbaric bupivacaine 0.5% associated with opioids is the local anesthetic the most commonly
used for spinal injection in cesarean section. Nevertheless, its use often results in a long
duration of motor nerve block and a haemodynamical instability. Recently developped, the
Prilocaine, with its new 2% hyperbaric formulation, seems to offer a good alternative for
hyperbaric bupivicaine. A first study has determined the ED95 of hyperbaric prilocaine 2% for
intrathecal anesthesia in scheduled cesarean delivery. As opioid adjuvants potentiate the
effect of the local anesthetics while decreasing their dose-related side effects, the aim of
this study is to determine the ED95 of hyperbaric prilocaine 2% with sufentanyl for scheduled
cesarean delivery under spinal anesthesia,by using the Continual Reassessment Method (CRM)
Clinical Trial – Effect of Intrathecal Morphine, Dexmedetomidine or Both in Combination to Bupivacaine on Immunity
this work aims to investigate the effect of intrathecal administration of Morphine,
Dexmedetomidine or both in combination on cellular immunity and cytokine production in
patients undergoing major abdominal cancer surgeries.
Ischaemia-reperfusion injury and hyperbaric oxygen pathways: a review of cellular mechanisms.
Abstract: Ischaemia-induced tissue injury has wide-ranging clinical implications including myocardial infarction, stroke, compartment syndrome, ischaemic renal failure and replantation and revascularization. However, the restoration of blood flow produces a 'second...