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Recent HBOT News
Comment on Fedorko et al. Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the Lower Limb: A Prospective, Double-Blind, Randomized Controlled Clinical Trial. Diabetes Care 2016;39:392-399.
Abstract: Löndahl, Fagher, Katzman, , , , , , (2016). Comment on Fedorko et al. Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the Lower Limb: A Prospective, Double-Blind, Randomized Controlled...
Response to Comments on Fedorko et al. Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the Lower Limb: A Prospective, Double-Blind, Randomized Controlled Clinical Trial. Diabetes Care 2016;39:392-399.
Abstract: Fedorko, Bowen, Jones, Oreopoulos, Goeree, Hopkins, O'Reilly, , (2016). Response to Comments on Fedorko et al. Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the Lower Limb: A...
Clinical Trial – Pharmacokinetics of Levobupivacaine After Cesarean Section
Transversus abdominis plane (TAP) block provides effective analgesia and is now a standard of
care for analgesia after cesarean section. There is no information on levobupivacaine
pharmacokinetics post TAP after pregnancy.
Objective: Generate a pharmacokinetic levobupivacaine model and its effect on the
electrocardiogram (ECG).
Method: The investigators will study 12 healthy term pregnant patients, scheduled for
elective cesarean section under spinal anesthesia. A bilateral TAP block is performed with 20
ml 0.25% levobupivacaine with epinephrine 5 ug/ml. Sensory block will be assessed at 1-2-6
and 12 hours post puncture. 2 ml of venous blood will be obtained at 2-5-10-30-45-60-90 and
180 minutes. With a Holter machine we will study the effect of levobupivacaine plasma levels
and the QTc changes.
Expected results: 1) Plasma levobupivacaine levels; 2) Changes in QTc .