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Recent HBOT News
MZF-1/Elk-1 interaction domain as therapeutic target for protein kinase Cα-based triple-negative breast cancer cells.
Abstract: Recent reports demonstrate that the expression of protein kinase C alpha (PKCα) in triple-negative breast cancer (TNBC) correlates with decreased survival outcomes. However, off-target effects of targeting PKCα and limited understanding of the signaling...
Clinical Trial – Spinal Anaesthesia and Severe Preeclampsia
The use of spinal anesthesia in pre-eclamptic pregnant woman is of considerable benefit, as
these patients present particular hazards with general anaesthesia, such as concerns for
rapid airway control and cerebral blood flow alterations during induction of general
anaesthesia and intubation However, the incidence of hypotension is high during spinal
anesthesia for Cesarean section and it may approach values up to 95 %.
Clinical Trial – Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia
Maternal hypotension is the most frequent complication of a spinal Anesthesia. The prevention
of spinal hypotension appears more likely to decrease the frequency and severity of
associated adverse maternal symptoms than the treatment of established hypotension.
Intravenous fluid administration prior to spinal anesthesia for caesarean section is accepted
standard practice. The choice of fluid depends on individual and institutional habit,
material cost (crystalloid is considerably cheaper) and the perceived relative benefits and
risks. Uncommon but potentially serious adverse effect of colloids is impaired coagulation.
Although pregnancy is associated with hypercoagulability, little is known about the effects
of colloid preloading on coagulation in pregnant patients.