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Recent HBOT News
A qualitative exploration of acute care and psychological distress experiences of ECMO survivors.
Abstract: To explore the acute care experience of extracorporeal membrane oxygenation (ECMO) patients. ECMO is used in life-threatening scenarios of acute lung or heart failure. The patient's experience with ECMO treatment and the psychological distress are unknown....
Clinical Trial – Dexmedetomidine for Sedation in Total Knee Replacements
Dexmedetomidine has demonstrated benefits both in sedation, and post-operative pain control,
with less respiratory depression than other common sedatives. Traditionally, dexmedetomidine
has been used with a large loading dose and infusion, which has been known to cause
dose-dependent negative side-effects (Abdallah et al., 2013). Single dose dexmedetomidine
produces less negative side-effects, but still effective sedation and reduced post-operative
pain (Jung et al., 2013). There is evidence for its benefits with general anesthesia but only
a few studies exist investigating its benefits when administered for sedation purposes with
spinal anesthesia, and no studies primarily examine post-operative opioid consumption. The
investigators hypothesize that single dose dexmedetomidine for procedural sedation will
reduce opioid consumption after total knee arthroplasty (TKA).
Hyperbaric oxygen in chronic traumatic brain injury: oxygen, pressure, and gene therapy.
Hyperbaric oxygen therapy is a treatment for wounds in any location and of any duration that has been misunderstood for 353 years. Since 2008 it has been applied to the persistent post-concussion syndrome of mild traumatic brain injury by civilian and later military researchers with apparent conflicting results. The civilian studies are positive and the military-funded studies are a mixture of misinterpreted positive data, indeterminate data, and negative data. This has confused the medical, academic, and lay communities. The source of the confusion is a fundamental misunderstanding of the definition, principles, and mechanisms of action of hyperbaric oxygen therapy. This article argues that the traditional definition of hyperbaric oxygen therapy is arbitrary. The article establishes a scientific definition of hyperbaric oxygen therapy as a wound-healing therapy of combined increased atmospheric pressure and pressure of oxygen over ambient atmospheric pressure and pressure of oxygen whose main mechanisms of action are gene-mediated. Hyperbaric oxygen therapy exerts its wound-healing effects by expression and suppression of thousands of genes. The dominant gene actions are upregulation of trophic and anti-inflammatory genes and down-regulation of pro-inflammatory and apoptotic genes. The combination of genes affected depends on the different combinations of total pressure and pressure of oxygen. Understanding that hyperbaric oxygen therapy is a pressure and oxygen dose-dependent gene therapy allows for reconciliation of the conflicting TBI study results as outcomes of different doses of pressure and oxygen.