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Recent HBOT News
Clinical Trial – Efficacy of the Combination of Isosorbide Dinitrate Spray and Chitosan in Diabetic Foot Ulcers
The prevalence of diabetic foot ulceration in the diabetic population is 4-10%; the condition
is more frequent in elder patients. It is estimated that about 5% of all patients with
diabetes present a history of foot ulceration, while the lifetime risk of diabetic patients
developing this complication is 15%. The majority (60-80%) of foot ulcers will heal, while
10-15% of them will remain active, and 5-24% of them will finally lead to limb amputation
within a period of 6-18 months after the first evaluation , 2 out of 3 patients with a limb
amputation could also be involved in a new amputation in the next year; higher or in the
other leg , Eighty-five percent of lower-limb amputations in patients with diabetes are
preceded by foot ulceration. The management of chronic diabetic foot ulcers (DFU) suggests
multi-disciplinary approaches including control of diabetes, orthotic shoe wear, off-loading
device, wound care and surgery in selected cases. However, treatment of DFU remains
challenging because of unsatisfactory results from surgical and non-surgical treatments. Many
adjunctive therapies are designed to improve the care of DFU including negative pressure
wound therapy , ultrasound, recombinant human platelet-derived growth factor-BB (rPDGF-BB)
Hyperbaric oxygen and acellular matrix product among others.
Clinical Trial – Hyperbaric Chamber for Central Retinal Vein Occlusion (CRVO) Patients
Hyperbaric chamber treatment assists in increasing the amount of oxygen in the plasma and in
the tissues and has been proven to be beneficial in treating different ischemic wounds, and
acute retinal artery occlusion (ARAO) but its effect hasn’t been tested in CRVO patients yet.
Pentoxifylline-tocopherol-clodronate combination: A novel treatment for osteoradionecrosis of the temporal bone.
Abstract: Osteoradionecrosis (ORN) of the temporal bone is a complication of radiation therapy that is extremely challenging to manage. We report the case of a patient treated at our institution and present a review of the literature. A 52-year-old woman presented...


