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Recent HBOT News
Peripheral nerve injury induces persistent vascular dysfunction and endoneurial hypoxia, contributing to the genesis of neuropathic pain.
Abstract: Nerve injury is associated with microvascular disturbance; however, the role of the vascular system has not been well characterized in the context of neuropathic pain. Furthermore, ischemia is thought to play a role in a number of neuropathic pain...
Clinical Trial – Use of Intrathecal Fentanyl and Development of Hyperalgesia in Patients Undergoing Elective Cesarean
Opioid analgesic drugs are the main treatment of patients during anesthesia. Although highly
effective, their use is not without problems. One is the increasing requirement of these
address the same nociceptive stimulus.
Opioid induced hyperalgesia could be an explanation studies in animal models. Through
mechanisms where N-methyl-D-aspartate receptors, glutamatergic system disturbances and
changes in intracellular calcium regulation involved.
The hyperalgesia induced by intrathecal opioids is controversial. The investigators propose a
model study in patients undergoing cesarean section to study the secondary hyperalgesia
induced based on the study of nociceptive thresholds with two methods opioids: Von Frey
filaments and digital algometer.
If intrathecal fentanyl is used in spinal anesthesia for elective cesarean section, then, an
increase in sensitivity will occur. This increase can be measured by von Frey filaments,
expressed in increased requirement clinically opioids.
Clinical Trial – Spinal Anesthesia Versus Combined Sciatic-femoral Nerve Block for Outpatient Knee Arthroscopy
The aim of the study is to compare the time of home discharge in day-case patients receiving
either a spinal anesthesia or a combined sciatic-femoral nerve block for knee arthroscopy