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Recent HBOT News
What is the role of hyperbaric oxygen in the management of bisphosphonate-related osteonecrosis of the jaw: a randomized controlled trial of hyperbaric oxygen as an adjunct to surgery and antibiotics.
Abstract: This study tested hyperbaric oxygen (HBO) as an adjunct to surgery and antibiotics in the treatment of bisphosphonate-related osteonecrosis of the jaw (ONJ) and evaluated its effects on gingival healing, pain, and quality of life. The investigators...
Clinical Trial – Effects of Levocetirizine and Hydroxyzine on Cognitive and Psychomotor Functioning During Simulated Diving
Antihistamines are commonly used and currently levocetirizine is most frequently prescribed
in the Netherlands. They are commonly used by divers, to solve ear, nose and throat problems,
especially to open tubal passage. However, the effects of these drugs on cognitive
performance have not been investigated during diving.The objective of this study is to
investigate the effects of levocetirizine, hydroxyzine and placebo on cognitive and
psychomotor functioning during controlled simulated diving in a hyperbaric chamber in
professional navy divers at 10 mt (2 bar) and 30 mt (4 bar).It is hypothesized that
hydroxyzine will produce significant impairment, and that the magnitude of impairment is
related to hyperbaric pressure.
The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxia.
Abstract: Benzotriazine-N-oxide bioreductive prodrugs such as tirapazamine and its improved analogue CEN-209 (SN30000) have potential for exploiting hypoxia in tumors. Here, we test the hypothesis that the 2-nitroimidazole EF5, in clinical development for both...