Clinical Trial – Comparing the Effects of Levobupivacaine and Bupivacaine in Saddle Spinal Anesthesia

İn this study; it was aimed to investigate the effects of equipotent doses of hyperbaric
bupivacaine and hyperbaric levobupivacaine in outpatient anorectal surgery under saddle
block. Sixty patients between the age of 18- 50 and in the risk group of ASA I-II included in
the study. 7,5 mg of 0,5% hyperbaric bupivacaine or 7,5 mg of 0,5% hyperbaric levobupivacaine
injected into the intrathecal space in sitting position through L4-L5 or L5-S1 intervertebral
space in 30 seconds. All patients kept in sitting position for 5 minutes with aid after
intrathecal injection and than layed in supine position, finally they positioned in prone
jack-knife. Hemodynamic parameters like NIBP, HR, SpO2, sensory and motor block
characteristics, duration of analgesia, time of first voiding, mobilization time, patient and
surgeon satisfaction, adverse effects and discharge time were recorded during and after
surgery.

Clinical Trial – Effect of Intravenous Magnesium on Post-spinal Fentanyl Induced Pruritus Incidence

Introduction: Adding opioids to local anesthetic solutions leads to enhanced anesthesia and
provide postoperative analgesia. Intrathecaly injected opioids have some side effects,
though. One of them is pruritus. Objective: We designed a randomized, double‐blinded,
placebo‐controlled study to evaluate prophylactic impact of continuous IV Magnesium 10mg/kg
over 30 minutes on intrathecal fentanyl‐induced pruritus start at the end of the operation.

Methods: ASA I‐II Patient’s candidate for orthopedic operations under spinal anesthesia
(10‐15mg hyperbaric bupivacaine and 25 µg fentanyl intrathecal) and will be divided randomly
into two groups:

Control group (Placebo group): bolus 100 ml nacl 0.9% at end of surgery Study group (Mg ++
group): (continuous IV Magnesium 10mg/kg in 100 ml Nacl0.9% over 30 minutes at end of
surgery).

Study outcome:

1. Hemodynamics: Systolic blood pressure, Mean arterial blood pressure, pulse rate, O2
saturation will be recorded in 5 min,10 min,30 min,60 min and every one hour till 6
hours after the operation.

2. Pruritus Patients were asked about existence (present=1,no=0), severity (mild=1,
modret=2, sever =3) and site of pruritus (Face(trigeminal) =1, neuroaxial(dermatome)=2),
1,2,4, and 6 hours after operation. Incidence of pruritus total group incidence %.

3. The incidence of PONV.

Clinical Trial – Effect of Intravenous Dexmedetomidine on Patient Discomfort in Laparoscopic Cholecystectomy Under Spinal Anesthesia.

Laparoscopic cholecystectomy (LC) has been routinely performed under general anesthesia
despite the several disadvantages of general anesthesia compared to regional anesthesia.

There are multiple reports that have been published regarding the feasibility of spinal
anesthesia for LC associated with many problems such as referred shoulder pain secondary to
intra-abdominal pneumoperitoneum; patient anxiety, pain, and discomfort; and inadequate
sedation.The aim of our study is to prospectively observe the feasibility of using
intravenous dexmedetomidine to abolish patient discomfort and shoulder pain, thus making the
patient more comfortable without causing excessive sedation and respiratory depression.